A new study published by the British Journal of Pharmacology and the National Institute of Health has found that THCV, and CBDV – two compounds found naturally in cannabis which aren’t psychoactive like THC – were both successful at reducing nausea in rat subjects.
For the study, researchers “evaluated two phytocannabinoids, cannabidivarin (CBDV) and Δ9 -tetrahydrocannabivarin (THCV) for their ability to produce these behavioural effects characteristic of CB1 receptor inverse agonism in rats.”
In doing so, researchers found that; “THC (2.5 and 10 mg kg-1 ), THCV (10 mg kg-1 ) and CBDV (200 mg kg-1 ) suppressed LiCl-induced conditioned gaping, suggesting anti-nausea potential.”
The study concludes; “The pattern of findings indicates that neither THCV nor CBDV produced a behavioural profile characteristic of CB1 receptor inverse agonists. As well, these compounds may have therapeutic potential in reducing nausea.”
This study indicates that it may be possible to use THCV or CBDV to help reduce nausea without bringing forth the psychoactive effects associated which THC, which may be seen as undesirable to some.
This research was funded in part by the Natural Sciences and Engineering Research Council of Canada.
The study can be found here: http://www.ncbi.nlm.nih.gov/pubmed/23902479